Mass Spectrometry

Pesticide and Mycotoxin Analysis: Mastering the Complexity of the Cannabis Matrix

Feb 28, 2018

The method described here allows for the simultaneous analysis of 47 pesticides and five mycotoxins in cannabis in one simple QuEChERS procedure. This simple method is designed for implementation in start-up laboratories and in established laboratories that wish to streamline their sample preparation process, decrease solvent usage, and obtain accurate and fast results.

Liquid Chromatography– Time-of-Flight Mass Spectrometry for Cannabinoid Profiling and Quantitation in Hemp Oil Extracts

Feb 28, 2018

A primary impediment to cannabinoid research is the fact that materials possessing psychoactive Δ9-tetrahydrocannabinol (THC) are considered Schedule I drugs as defined in the U.S. Controlled Substances Act. An alternative source of cannabinoids may be found in hemp oil extracts. Hemp contains a low percentage of THC by weight but relatively high amounts of nonpsychoactive cannabinoids. The liquid chromatography–time-of-flight mass spectrometry (LC–TOF-MS) method presented herein allows for the accurate, precise, and robust speciation, profiling, and quantification of cannabinoids in hemp oil extracts and commercial cannabinoid products for research and development laboratories. The method was determined to chromatographically separate 11 cannabinoids including differentiation of Δ8-tetrahdrocannabinol and THC with excellent linear dynamic range, specificity, and sensitivity.

Using Compact Mass Spectrometry for Detection and Quantification of Cannabis-Related Compounds

Feb 27, 2018

Compact mass spectrometry, in combination with suitable sample introduction techniques—such as the atmospheric solids analysis probe, thin-layer chromatography, and classical liquid chromatography techniques—can be used effectively for the detection and quantification of cannabinoids and pesticides in cannabis-related material and contraband.

Rapid Determination of 24 Synthetic and Natural Cannabinoids for LC–MS-MS Screening in Natural Products and Drug Inspection Applications

Feb 26, 2018

Other techniques for monitoring cannabinoids, such as GC–MS and LC–MS, are limited to screening known species and are therefore always one step behind the designer drug market—where new, previously unknown variations of analogs of cannabinoids are constantly being synthesized. The method presented here addresses this problem by providing accurate masses for all detected species, thus allowing postanalysis identification of initially untargeted compounds.

Monitoring Medical Cannabis

Jan 26, 2018

Giuseppe Cannazza and Cinzia Citti from the University of Modena and Reggio Emilia discuss the growing interest in the use of medicinal cannabis in Europe and the analytical challenges involved.

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