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Hemp and marijuana are becoming more popular because of legalisation in multiple countries. The increase of this market also increases the offer of products and therefore the need to monitor different components. One of these components are cannabinoids or just short potency analysis, which can be found in our portfolio of Cannabis applications (AN091,92,93,130). This application focusses on terpenes analysis.

Determination of Terpenes in Cannabis by GC-FID (using 8300 GC / 8500 GC)

CBDV, CBGA, THC-A and CBDA cannot be detected with FID or MS without extra sample preparation due to decarboxylation caused by the heat of the injector. The HPLC is a perfect instrument to measure these components since it does not use heat for the injection. Discover the advantage of this technique being able to analyse acidic cannabinoids without the lengthy sample preparation seen in GC methods.

Cannabis Potency Analysis by HPLC (June 2024)

Residual Solvents are organic volatile products that are often used for the extraction of CBD and THC from marijuana leaves. Unfortunately these Residual Solvents can cause health risks when after extraction these components are not removed accurately. Therefore it is important to monitor these components to asses the quality and safety of the product for safe consumption. This application note will help you to ensure safety of your cannabis products with our easy to follow steps on sample preparation, method conditions and validation.

Residual Solvents in Cannabis by HS-GC-MS

This application focusses on the analysis of potency using the GC-MS. SCION Instruments has an extended portfolio including potency analysis with an FID (AN091, 92, 93 and 130), terpene analysis (AN133 and 136) and Residual solvents analysis (AN139). This application is applicable on the SCION Instruments 4X6 in combination with the SCION single quad (SQ). But the analysis was performed on the SCION Instruments 8X00 GC series with the new 8700 SQ mass Spectrometer.

Cannabis Potency analysis by GC-MS

Hemp and marijuana are becoming more popular because of legalisation in multiple countries. The increase of this market also increases the offer of products and therefore the need to monitor different components. One of these components are cannabinoids or just short potency analysis, which can be found in our portfolio of Cannabis applications (AN091,92,93,130). This application focusses on terpenes analysis using GC-SQMS, for Terpene analysis using GC-FID

Cannabis Terpene Analysis by GC-MS SQ

Cannabis potency can be determined using a number of analytical techniques. In this application note we will describe a
method using Gas Chromatography with a Flame Ionisation Detector (GC-FID). SCION also has application notes discussing other techniques such as HPLC (AN145) and GC-MS (AN142), these can be found on our website.
Helium has been the standard carrier gas for GC applications however, due to recent global shortages many companies are keen to find alternatives.[3] This application note will give a comparison between different carrier gases showing the variation in results between the two alternatives to Helium; Hydrogen and Nitrogen.


Cannabis Potency by GC-FID with Carrier Gas Comparison (Helium, Hydrogen, Nitrogen)

Post ingestion, Δ 9 THC is metabolised into the inactive ingredient Tetrahydrocannabinolic Acid ( THC COOH)
Suspected drug drivers are often subjected to a screening test of cannabinoids in saliva A positive result must then be confirmed by the presence of Δ 9 THC in a blood sample by gas chromatography.  Quantification of  THCA can indicate long term use of the drug.  Drug detection limits are set by government laws and vary from country to country The limits in the United Kingdom and Canada is 2 ng/mL whereas in France the limit is 1 ng/ mL


Optimal Quantification of THC in Blood (using SCION 8300/8500 GC, Autosampler and SCION 8700 SQ MS)

With the different hemp and cannabis products on the market, all with various levels of cannabinoids, quality control to monitor the level of cannabinoids is crucial.